1 Roos Jump Rope – Adjustable – Best for Boxing – Cardio Endurance Fitness Training – Bonus FREE core workout & FREE E-book + Carrying bag – Used at all levels by Men,Women & Kids.

Did you know that jumping rope burns from 800 to 1000 calories per hour.

The 1 Roos Jump Rope is Great for: playground game, competitive sport and serious cardiovascular training. Perfect for boxing, MMA, and CrossFit lovers- Work on your cross overs, side jumps, and double unders to build endurance and stamina.

– Improves Heart and Health, making it easier to breath
– Improves muscle tone and confidence
– Promotes the greatest amount of weight loss in the healthiest possible manner

Custom foam grips are designed to reduce hand fatigue during longer workouts.

1Roos jump rope’s cable is crafted with speed ball-bearings to allow for smooth and consistent rotation. Made with premium quality 3M PVC- designed for long term, intense usage.

Benefit/Feature/Bonus Gift/Differentiator

– Effective in building endurance, stamina, and speed
– Saving you thousands in the long run
– You can take them with you, Holiday, traveling Whether you’re raising a kid a boxer or just love exercise, this heavy-duty nylon rope is perfect for sports training, school activities or recreational use at home.

The manufacture,1 Roos,offers a lifetime Guarantee. If you don’t love it for any reason simply contact the manufacture for a complete no hassle refund.

Product Features

  • * BEST EFFECTIVE TRAINING – In building endurance, stamina, and speed, Improves muscle tone and confidence, Builds cardio endurance, develops core strength and agility, and improves lower body muscle tone
  • * MAXIMUM COMFORT – The handles are lightweight and coated with custom memory foam grips for extra comfort
  • * FULLY ADJUSTABLE – The quick cable length adjuster inside each handle means that the jump rope can be used by the entire family and training partners alike. The cable supplied will suit heights between 5’0″ to 6’8″ for men, women and children.
  • * BONUS TRAINING VIDEO+ E-BOOK- It Gets emailed to you “Core workout” training video both valued over $25.97.A World expert will show you Core routines for beginners, intermediate and advanced levels making it perfect for adult men and women and also your kids. You will also receive a downloadable eBook with valuable exercise tips to help you work out more efficiently.
  • * SMOOTH & FAST – The high speed ball bearing system in the handles and the polymer coated speed cable ensures you get the smoothest and fastest rotations ensures less hand fatigue and increased comfort, to give you the edge over your competitors.

Reblogged 2 months ago from www.amazon.com

Extreme Testosterone Booster – Natural Supplement With Raw Tribulus Terrestris and Horny Goat Weed to Increases Drive and Libido, Build Muscle Mass and Lose Fat, Improves Stamina and Energy Levels

Nutra Rise Performance Testosterone booster for men. Testosterone is a coveted chemical in the male physique and we created a safe and effective way to increase your body’s free testosterone. Testosterone levels can be increased naturally, through nutrition and science. Our Testosterone supplement is an all-natural testosterone formula. Whether you are a fitness pro, or just trying to get into shape, our blend is certain to meet the desires of the most discriminating customer.

Product Features

  • 100% NATURAL TESTOSTERONE BOOSTER: Nutra Rise Test Boost contains 100% pure, natural Raw Bulgarian Tribulus Terrestris. It is a plant-derived ingredient which contains Steroidal Saponin to naturally increase testosterone. Benefits include increased muscle growth, strength and enhanced athletic performance – Great benefits for men and women at the gym, for pre-workout, recovery, vitality, overall health & wellness. Check out our excellent Customer Reviews!
  • CONTAINS LONGJACK: Longjack is a rare herb found in the rain forest of Indonesia. It naturally raises your body’s levels of “free” testosterone. A large proportion of the testosterone in your body is bound by a protein called SHBG. Testosterone that is bound to SHBG is considered ineffective. Only free testosterone provides the desired anabolic muscle building and androgenic libido effects.
  • GET MAXIMUM RESULTS: In addition to its powerful libido increasing properties, it also improves muscles mass, boosts energy in workouts,and increases bone mineral density. Our Testosterone Booster can bring back youthful energy and performance in all areas of life with long term use. Get control of your health and vitality by increasing your body’s natural production of free testosterone.
  • BOOSTS STAMINA AND LIBIDO! Our formula helps provide energy, stamina and sexual desire. Three capsules per day can boost sex drive, and libido. Check out our Amazon reviews!
  • PURE & POTENT: Nutra Rise Testosterone Boost is 100% safe and natural. We do not use any fillers or artificial ingredients. We use only the very best, scientifically-tested ingredients, all of which are manufactured with strict adherence to GMP (Good Manufacturing Practices) standards. Every batch is third party tested to ensure that we only utilize ingredients that are safe and pure.

Reblogged 8 months ago from www.amazon.com

PCT Bodybuilding 100% Natural | Maintain Muscle Mass, Restore normal hormone levels, Support Testosterone levels (60 capsules)

Natural Post Cycle Therapy (PCT) is used to help restore the body’s hormonal systems after a cycle of anabolic supplement use. Once the supplement cycle has ended the body needs help to restore it to balance. PCT is safe and effective in helping the body restore the hormone levels to normal while maintaining muscle mass and not damaging other body systems.

Natural Post Cycle Therapy supplement is essential after an anabolic supplement cycle; it helps the body’s get natural energy and contains antioxidant that enhance liver health. Provided in easy to swallow capsules.

Product Features

  • 20% OFF TODAY off of MEGATHOM supplement for 5 products PCT (with the use of code ” VXPPJ4WP”. Get 15% OFF for 3 products with code ” 6QYZTJ2E” or 10% OFF for 1 product with code ” ONDXHKXK” | Best Nighttime Recovery Formula
  • BEST QUALITY: 100% safe and natural. No fillers or artificial ingredients. We use only the very best, All of which are manufactured in our US, FDA-inspected, state-of-the-art, facility, with strict adherence to good manufacturing practices. We only utilize ingredients that are safe and pure | To Support Growth, Strength And A Restful Sleep
  • GUARANTEED RESULTS OR MONEY BACK: MEGATHOM products never compromise on quality and always include clear and complete supplement facts. We stand by our products 100%. If you are not completely satisfied with any MEGATHOM product, we will help you resolve your concern or provide a full refund.| Supports Protein Synthesis
  • MEGATHOM stands by every quality product we make. We manufacture only high quality and extra pure but high potency vitamins, capsules, pills, tablets, powders, multivitamins, supplements, topical creams, liquids, serums, vegan foods, and natural organic-based extracts for men and women. Try MEGATHOM out today and see what it can do for you ! | Fast Muscle recovery
  • PCT Bodybuilding 100% Natural | Maintain Muscle Mass, Restore normal hormone levels, Support Testosterone levels (60 capsules)

Reblogged 1 year ago from www.amazon.com

Nutrafx ZMA 180 Caps | Best Muscle Builder | 490mg Trademark ZMA – Zinc, Magnesium and Vitamin B-6 Supplements Supports Healthy Testosterone levels | Bodybuilding Pills 180 Caps

Athletes professional and otherwise must maximize their sleep period because poor, restless sleep negatively affects performance levels. That’s why NUTRAFX ZMA is here. This cutting-edge anabolic mineral support formula containing MAGNESIUM ASPARTATE (150MG@20%) helps deliver the best sleep possible. Along with more effective sleep patterns, enjoy a wide array of benefits that includes increased testosterone levels and more complete muscle growth and recovery. NUTRAFX ZMA brings that extra edge in helping your body recover from intense workouts. You wake up ready to take that next workout through the roof, as well as attack the day with levels of energy like you’ve never felt before.

Product Features

  • TRADEMARK ZMA Formula Zinc Magnesium And Vitamin B-6
  • MUSCLE GROWTH: Increase muscle growth with post workout body recovery by Sleeping Easy.
  • DESIGNED FOR THE BODYBUILDER: How it works; ZINC Body Relaxer allows you muscle tissue to recover; MAGNESIUM for energy production; VITAMIN B-6 relieves Water Retention and Prevents Inflammation; both key factors in a good bodybuilding workout recovery
  • BENEFITS: Men can enjoy the benefits of Zinc relaxer

Reblogged 1 year ago from www.amazon.com

Z-BUILD–OVERNIGHT ANABOLIC MUSCLE BUILDER–60 Capsules: Scientifically designed to promote deeper sleep while maximizing both anabolic muscle support through increased testosterone levels, reduced estrogen, and accelerated recovery speed.

Boost Testosterone and build muscle all night long! WHY IT WORKS: During stages 3 and 4 of non-R.E.M. sleep is when your body is most productive, repairing bone and muscle tissue, boosting immune system, and releasing powerful muscle building and fat burning hormones. Z-BUILD is designed to get you to these stages faster and keep you there longer, while providing the essential building blocks to increase androgenic support and build and repair muscle in these critical and opportune stages. We have created Z-BUILD using potent and precise amounts of clinically tested ingredients, that intelligently work together to optimize sleep cycles and the important nightly stages of repair and recovery, while utilizing them as an effective platform to boost androgens, minimize estrogenic effects, and maximize total anabolic growth overnight! Includes: Tribulus Terrestris, Fenugreek Seed, Boron Citrate, Ashwagandha, Mucuna Pruriens, Stinging Nettle, DIM, ZMA and more! Z-BUILD is the final step to propel you to the next level–scientifically formulated with clinically trialed ingredients shown to work cohesively with your body throughout the night to: • Increase Both Free And Total Testosterone Levels • Suppress Estrogen And Supports Androgen Release • Maximize Muscle Growth And Promote A Deeper More Productive Sleep • Enhances Vitality And Libido Separate yourself from the rest with unheralded 24 hour muscle growth support! Get yours today!

Product Features

  • Z-BUILD is the NEXT LEVEL in anabolic muscle growth, combining an entire nights worth of pro-androgenic support while limiting estrogenic effects and maximizing the repair and recovery necessary to reap MASSIVE gains. Perfect to stack with any day time regiment for 24 hour anabolic support!
  • Not only will you receive all the restorative benefits associated with a deeper more productive sleep, but you will FEED your muscles with the androgenic fuel needed to propel you towards your ultimate potential – ALL NIGHT LONG.
  • Using Andro-BolicTM Muscle Building Technology, this formula creates the perfect synergy of androgenic and anabolic support necessary to maximize muscle gains and achieve unheralded results – separating the MEN from the BOYS.
  • Increase Both Free And Total Testosterone Levels, Suppress Estrogen And Accelerated Recovery Speed.
  • Maximize Muscle Growth And Promote A Deeper More Productive Sleep, and Enhances Vitality And Libido. All Natural and Stimulant Free!

Reblogged 2 years ago from www.amazon.com

Z-BUILD–Overnight AndroBolicTM Muscle Building Formula–60 Capsules: Scientifically designed to promote deeper more productive sleep while maximizing both anabolic and androgenic muscle support through increased testosterone levels, reduced estrogen output, and elevated Growth Hormone release, allowing for maximum repair, recovery, and overall muscle growth!

WHY IT WORKS: During stages 3 and 4 of non-R.E.M. sleep is when your body is most productive, repairing bone and muscle tissue, boosting immune system, and releasing powerful muscle building and fat burning hormones. Z-BUILD is designed to get you to these stages faster and keep you there longer, while providing the essential building blocks to increase androgenic support and build and repair muscle in these critical and opportune stages. We’ve created Z-BUILD using potent and precise amounts of clinically tested ingredients, that intelligently work together to optimize sleep cycles and the important nightly stages of repair and recovery, while utilizing them as an effective platform to boost androgens, minimize estrogenic effects, and maximize total anabolic growth overnight! Includes: Tribulus Terrestris, Fenugreek Seed, Boron Citrate, Ashwagandha, Mucuna Pruriens, Stinging Nettle, DIM, ZMA and more! Z-BUILD is the final step to propel you to the next level–scientifically formulated with clinically trialed ingredients shown to work cohesively with your body throughout the night to: • Increase Both Free And Total Testosterone Levels • Suppress Estrogen And Supports Growth Hormone Release • Maximize Muscle Growth And Promote A Deeper More Productive Sleep • Enhances Vitality And Libido Separate yourself from the rest with unheralded 24 hour muscle growth support! Get yours today!

Product Features

  • Z-BUILD is the NEXT LEVEL in anabolic muscle growth, combining an entire nights worth of pro-androgenic support while limiting estrogenic effects and maximizing the repair and recovery necessary to reap MASSIVE gains. Perfect to stack with any day time regiment for 24 hour anabolic support!
  • Not only will you receive all the restorative benefits associated with a deeper more productive sleep, but you will FEED your muscles with the hormonal balance and androgenic fuel needed to propel you towards your ultimate growth potential – ALL NIGHT LONG.
  • Using Andro-BolicTM Muscle Building Technology, this formula creates the perfect synergy of androgenic and anabolic support necessary to maximize muscle gains and achieve unheralded results – separating the MEN from the BOYS.
  • Increase Both Free And Total Testosterone Levels, Suppress Estrogen And Supports Growth Hormone Release
  • Maximize Muscle Growth And Promote A Deeper More Productive Sleep, and Enhances Vitality And Libido. All Natural and Stimulant Free!

Reblogged 2 years ago from www.amazon.com

Genesis Resistance Band Set and eBook (13 Pieces), Includes: 2 Ankle Strap Attachments, 2 Handle Attachments, a Door Anchor, 5 Resistance Bands with Different Levels of Resistance (6 Lbs., 8 Lbs., 12 Lbs., 18 Lbs. and 22 Lbs.), Informational Inserts, a Handy Storage Bag and a Free PDF Copy of the Kindle Book – Resistance Band Genesis

About the brand
Fitness should be affordable, it should be complementary to daily life. Better health shouldn’t require on-going financial commitments. The Genesis brand is about products that contribute to real success, at a fair value, with no strings attached.

Efficient, effective, economical and easy
Resistance bands are an excellent component of any fitness program:
– They are effective in building, toning and stretching all the major muscle groups.
– They support home based/ mobile fitness programs (e.g. boot camps) because they are small and light-weight making them easy to store and transport.
– They are safe, and convenient, when compared to equipment that requires heavy weights, or multiple weights, to be effective.
– They do not rely on gravity to create resistance, meaning less strain on non-target areas (e.g. your back) and more options for exercise variety.
– Resistance bands are easy and do not require training/ experience to create an effective fitness program.

What’s in a set?
– 5 bands ( 6 lbs., 8 lbs., 12 lbs., 18 lbs. and 22 lbs.)
– 2 padded handles
– 2 ankle straps
– 1 door anchor
– 2 information inserts
– 1 black storage bag
– 1 PDF of the Kindle eBook Resistance Band Genesis, delivered through Amazon’s email when confirmation of an order is received

Benefits
1. Number of exercises and variations available
2. You can target all your major muscle groups
3. Effective in development, toning, flexibility and joint stabilization
4. Compact design/ light weight
5. Ease and simplicity
6. Adaptability to your needs and requirements
7. Inexpensive
8. Safe

Product Features

  • • 5 individual resistance bands, made of 100% Malaysian latex, that can be used individually or jointly to deliver resistance tensions form 6 lbs. to 66 lbs. to target all your muscle groups.
  • • 5 Attachments (2 ankle, 2 handle and a door anchor) to allow for all manner of exercise and anchor positions. A full workout program with no further investment required, perfect if you want a fitness program without major financial investments, on-going financial commitments or commutes to the gym.
  • • Small and compact equipment in a convenient storage bag perfectly suits your home or mobile fitness program, whenever and wherever your workouts take place. The equipment can be taken out when you need it and easily stored when you don’t.
  • • Resistance bands utilize elastic resistance not gravitational resistance, which gives you total flexibility in terms of body positioning, exercise customization and conformity to your surroundings.
  • • The PDF version of the Kindle book Resistance Band Genesis has over 120 pages of information, exercises, advice and guidance. There are more than 70 exercises described in detail in a simple, straight forward format (band set-up, starting position, exercise movement and target muscles). Each exercise s captured in pictures identifying the start and end postures. The PDF can be opened on your tablet, your computer or your smartphone (e.g. iBooks) or you can choose to print out a copy (although it is very comprehensive). The PDF is a constant and convenient companion to your resistance band fitness program. The PDF will be delivered via the Amazon email system when confirmation of an order is received.

Reblogged 3 years ago from www.amazon.com

#1 Testosterone Booster Supplement TEST WORx – 6 Week Cycle – 100% Made in the USA- 100% MONEY BACK GUARANTEE-Ingredients clinically proven in HUMAN trials to improve testosterone levels up to 132%

TEST WORx USA’S #1 BEST SELLING TESTOSTERONE BOOSTER

TEST WORx® contains the most potent and biologically active EuryPeptides® created by the original researchers at the University Malaya and MIT to increase Free Testosterone(FT) and unbind bound testosterone. TEST WORx® ingredients have studies published in the British Journal of Sports Medicine, The Journal of International Society of Sports Medicine and the International Journal of Andrology and Asian Journal of Andrology.

Most Customers Report Results Within 2-3 Weeks

– Natural and Safe Ingredients

– Dramatic increases in energy and Libido

– Noticeable reduction of fat in mid section

– Long Lasting 6 Week Supply

– Improves muscle recovery time

– Increased mental focus and clarity

TEST WORx® unbinds Bound Testosterone(BT) and improves Free Testosterone(FT) without increase in aromatization into estrogen. TEST WORx® proprietary blend signals the hypothalamus and pituitary glands to naturally enhance your own testosterone levels. This product will not shut down natural testosterone producing capabilities after stopping use.

Sex Hormone Binding Globulin(SHBG) binds a high percentage of testosterone to fat cells making it inactive. When testosterone is bound, it becomes unable for use in the body. Free Testosterone is responsible for providing the body with energy, mood enhancement, increasing and maintaining muscle mass and enhancing sex drive. TEST WORx® improves Free Testosterone bio availability and aids in decreasing levels of SHBG.

Product Features

  • USA’S #1 BEST SELLING Natural Testosterone Booster. Ingredients clinically proven on humans (not animals) to Increase Testosterone Levels. Contains the most potent, biologically active EuryPeptides on the market today created by the original researchers at university of Malaya and MIT
  • PROVEN- Increase testosterone Up to 132% within 2-4 weeks
  • UNIQUELY POWERFUL- made in usa under safe fda & cgmp certified & regulated Facilities
  • PHENOMENALLY EFFECTIVE- potent blend of ingredients long lasting 6 WEEK CYCLE.
  • NOTICEABLE INCREASES – In energy, libido, recovery and mood within 2-4 weeks – 100%MONEY BACK GUARANTEE

Reblogged 3 years ago from www.amazon.com

#1 Best Natural Testosterone Booster for Men **100% MONEY BACK GUARANTEE** More Energy, Muscle Growth, Weight Loss and Libido – All Natural Herbal and Vitamin Testosterone and Muscle Building Supplement Pills Without Steroids – With Tongkat Ali (LongJack) Extract, PROVEN To Increase Free Testosterone Levels – Made in GMP & FDA Approved USA Facility – 30 Day Supply – 60 Capsules – Boost Your Test, Lean Muscle Mass and Energy Levels Naturally or Your Money Back Guaranteed

If you’re ready to unleash your natural ability to build lean muscle mass, eliminate stubborn fat, and increase your sex drive like never before, Test Surge is the best testosterone booster for men you’ve been looking for. Here’s why…

TestSurge provides the body with muscle mass, limitless energy, elevated mood, and an insatiable sex drive because of its high-strength, all-natural formula with key ingredients CLINICALLY PROVEN to boost the production of free and total testosterone with tongkat ali extract and zero unwanted side effects.

In fact, our formula is so potent and so powerful here are some of the things you will experience:

– Dramatic increase free and total testosterone levels for maximum muscle growth

– Improvement in muscle recovery time

– Noticeable reduction of fat

– Higher levels of energy and focus

– Enhanced mood levels and cognitive ability

Don’t waste time and money on other test boosters that make false claims or settle for sub-par production standards. Test Surge is the Gold Standard of Testosterone boosters. This amazing product is made in the USA from start to finish in a GMP and FDA accredited facility.

We believe men and women deserve to maximise their testosterone levels and build lean muscle. That is why, we are providing YOU with FREE shipping wherever you are in the USA.

Because we back our product, we will shoulder all of the risk. If you are in any way unsatisfied with the results you gain from Test Surge, we offer a 100% Money Back Guarantee.

Want to know how to maximize your muscle building efforts with Test Surge? We have got you covered. For a LIMITED-TIME ONLY, you can get the popular eBook, How To Build Muscle, Lose Fat and Create The Body of Your Dreams, absolutely FREE with your purchase.

Click the ADD TO CART button above if you’re ready to kick your fitness efforts into overdrive. Consider ordering 2 bottles for uninterrupted use.

Product Features

  • FREE SHIPPING – When you purchase today, there are zero additional fees. We believe you deserve to maximise your testosterone levels and build lean muscle. That is why, we will ship TestSurge to you wherever you are in the USA, absolutely FREE! We are also throwing in for a LIMITED-TIME ONLY the eBook, How To Build Muscle, Lose Fat and Create The Body of Your Dreams, which will help maximise your muscle building. It is yours to keep.
  • 100% MONEY BACK GUARANTEE – Because we back our product, we will shoulder all of the risk. If you are in any way unsatisfied with the results you gain from TestSurge, you can get a full refund. No questions asked. No hassle. So click the “Add to cart” button and start boosting your testosterone now!
  • TESTSURGE TESTOSTERONE BOOSTER WORKS!! A human study in the Journal of Phytotherapy Research on Eurycoma Longifolia (LongJack) at the same daily dose found in TestSurge showed “significant increases in total and free testosterone concentrations and muscular force in men and women”. That is unheard of in a human clinical trial for a herbal supplement. Remember you get what you pay for. Cheaper products have 3 things in common: inferior ingredients, lower mg count per capsule and lower recommended dosages.
  • MORE THAN JUST MUSCLE GROWTH – In addition to its powerful testosterone and muscle building properties, ingredients in our TestSurge supplement has been shown to be energy and libido enhancers. If you are 30+ chances are your testosterone levels are on the decline and you are struggling to lose fat, add lean muscle, have lower energy and less stamina in the bedroom. Take control of your energy and body composition with our easy-to-use TestSurge! Wouldn’t it be nice to be happier, have more energy, sleep better at night, get your figure back, AND become healthier – all at once?
  • 100% SAFE WITH NO UNWANTED SIDE EFFECTS – TestSurge is a high strength, all-natural formula of potent extracts clinically proven to boost production of free testosterone with no undesirable side effects. You won’t find any dangerous steroids or other banned substances in our product. Our amazing product is made in the USA from start to finish in a GMP and FDA accredited facility. Do not settle for sub-par production standards or unproven competing products. TestSurge is the Gold Standard of Testosterone boosters.

Reblogged 3 years ago from www.amazon.com

Anabolic Steroid Use and Elevated Liver Enzyme Levels

Your liver is your life. That sounds like a grandiose statement, but it’s true. The human liver is located behind the lower ribs, right below the diaphragm on the right side of the abdomen. It averages slightly more than three pounds in weight and is six inches thick. Without a functioning liver, you’d die a miserable death. Common food elements like protein would put you into a coma, since the by-products of protein metabolism, such as ammonia, would increase in the blood. In fact, many common food elements and drugs would prove fatal if you didn’t have this organ around to render them innocuous.

The liver is a potent chemical-processing plant. It quietly performs more than 500 vital functions, including the following:

  • Manufactures bile, which is needed for complete fat absorption.
  • Converts protein, carbohydrate and fat into other elements.
  • Metabolizes drugs, including alcohol.
  • Cleanses the blood of toxins.
  • Produces blood-clotting factors, without which a minor cut could prove fatal.
  • Stores nutrients—such as fat-soluble vitamins A,D, E, and K; vitamin B12 and carbohydrate—as glycogen.
  • Maintains blood glucose levels by way of liver glycogen breakdown and release into the blood as glucose.
  • Synthesizes cholesterol and protein carriers for cholesterol in the blood.
  • Produces immune factors that protect against disease.

That’s just a partial list. Obviously, you want to maintain proper liver function for maximum health. Many things are known to harm the liver, including excessive alcohol intake and drug use. From an athletic standpoint, certain types of anabolic steroids are frequently mentioned as having bad effects on liver function. They’re usually oral drugs that are classified as 17-alpha ankylated drugs.

The designation “17-alpha ankylated” refers to a change made on position 17 of the basic steroid structure. Scientists developed the testosterone derivatives after noticing that orally taken testosterone is degraded in the liver in a process called first-pass metabolism. Drug developers circumvented that formidable problem by making testosterone available in an injectable form, which bypasses initial first-pass liver metabolism, and by manipulating the basic steroid chemical structure, as is the case with oral 17-alpha ankylated anabolic steroids.

While the structural change in oral anabolic steroids did result in a far slower rate of breakdown in the liver, it also led to an inordinate buildup of such drugs in the liver. Since the injectable versions of steroids don’t build up in the liver as much as oral versions, the injectables are considered less of a problem in terms of normal liver function.

The oral drugs adversely affect the liver through several mechanisms. For example, they interfere with the function of certain liver enzymes. Anabolic steroids are known to increase the activity of some liver enzymes while downgrading that of others. One enzyme that’s increased with oral anabolic steroid use is hepatic triglyceride lipase, which degrades high-density lipoprotein (HDL), a beneficial cholesterol carrier in the blood. A lowered HDL level is considered a risk factor for cardiovascular disease. Athletes who use oral anabolic steroids nearly always show depressed HDL levels. The buildup of 17-alpha ankylated oral anabolic steroids in the liver leads to a type of toxic or chemical hepatitis. Hepatitis, by the way, is a general word for an inflammation of the liver and can be caused by various factors, such as drug use and viruses. Oral steroids cause liver inflammation by promoting an increase in the size of liver cells, which leads to a congestion of bile flow through ducts in the liver that empty into the gallbladder, where bile is stored.

The interference with bile flow induced by the effects of anabolic steroids on liver cells is called cholestasis. It usually occurs only in people who use higher doses of oral steroids or who use such steroids for extended periods of time. Certain oral steroids are reputed to have more potent toxic effect in the liver and to promote the liver swelling that can lead to cholestasis. They include Oxymetholone (Anadrol) and Fluoxymesterone (Halotestin), although it may be that those drugs cause problems because they’re often used in higher doses than other oral steroids. Both drugs are 17-alpha ankylated, as are most oral steroids.

According to existing medical research, most cases of serious liver ailments due to oral anabolic steroid use have involved hospitalized patients who were given oral steroids such as Anadrol to combat rare blood anemias. Many stayed on oral steroids for three or more years. The consensus of medical reviews is that certain potentially adverse liver changes do occur with athletic use—with the extent of the changes again depending on the drugs used, the doses and the length of time—but the changes regress when the athletes stop using the steroids. The liver is known to have an amazing capacity for regeneration unless it’s irrevocably damaged, a scenario that rarely occurs with short-term steroid use.

Physicians often warn about elevated liver enzyme levels due to oral anabolic steroid use. While that could indicate an inflammation of the liver, the problem is that some of the measured liver enzymes aren’t specific to the liver and exist in other tissues. For example, two enzymes found in liver, ALT and AST, also exist in muscle. Any type of injury to muscle—including the kind that occurs with intense weight training—causes an elevation of those enzymes in the blood. A physician who’s not looking at the big picture—or measuring levels of other liver and muscle enzymes—may wrongly conclude that such liver enzyme increases are indicative of liver problems. Measuring enzymes such as creatine kinase and GGT would provide a more definitive picture of existing liver function, as would liver imaging tests.

One visible early sign of liver inflammation due to oral steroid use is jaundice, which is characterized by a retention of bile in the body, leading to a yellow discoloration in the skin and whites of the eyes. Anyone using oral anabolic steroids should stop using them immediately if such symptoms occur. If you ignore the symptoms, you’re at risk for a more serious liver complication.

Peliosis hepatis, as it’s called, consists of blood-filled cysts in the liver. It’s thought to be due to cholestasis; that is, the elevated pressure in liver tissue brought about by lack of proper bile flow in the liver leads to a breakdown of liver cells followed by the appearance of the cysts. The blood-filled cysts can rupture, leading to death. Most cases of peliosis have occurred in hospitalized patients on long-term steroid therapy, although the occurrence of peliosis isn’t dependent on dosage.

One published instance of peliosis involved a 27-year-old bodybuilder who was using a steroid stack consisting of oxandrolone (Anavar), methandrostenolone (Dianabol), nandrolone (Durabolin) and testosterone for five weeks. What he took before that time wasn’t disclosed in the published report. The interesting aspect is that the drug stack he used isn’t considered highly toxic to the liver. The bodybuilder may have used more toxic oral steroids over a longer period, however, or he may have taken a drug such as Nolvadex, an estrogen blocker that few bodybuilders know can also cause peliosis if used in too high a dose for too long.

The other serious liver disease often linked to oral anabolic steroid use is liver cancer. Reviews of liver cancer in various medical journals indicate that it’s of a more benign nature than other cancers. Simply put, the liver tumors that develop with steroid use usually regress if the person stops using the drugs. That’s not always the case, however.

Reblogged 3 years ago from cuttingcyclesteroids.tumblr.com