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Reblogged 1 month ago from www.amazon.com

Vegains – Vegan Gains – Bodybuilding & Fitness Men & Women

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Reblogged 2 months ago from www.amazon.com

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Reblogged 2 years ago from www.amazon.com

Testosterone Undecanoate: Big Gains or Big Pain?

Nearly every recreational user of anabolic steroids accepts the legal and health risks in order to improve his quality of life – a more impressive physique, greater confidence, or a competitive edge. Yet, despite the tangible benefits conferred by anabolic steroids, there are a number of pains that users face.

In the practice of pharmacy, compliance is a major issue that determines the success of a drug treatment. Compliance means the patient following directions. To combat the habit of noncompliance, drug therapies are designed to be as effortless as possible. Thus, most oral drugs are once-daily; imagine the consequences of failing to take birth control as scheduled.

Most women follow a once-daily birth control pill schedule, but it is inconvenient. Thus, long-acting birth control options have been developed that allow for the placement of hormone-infused silicone implants lasting five years, or an intramuscular injection lasting 12 weeks. The same delivery systems used to provide long-acting female sex steroid hormones can also be applied to male sex steroid hormones, such as anabolic steroids.

Anabolic steroids users already depend upon injectable anabolic steroids rather than orals, due to their higher potency, convenience, and to avoid the liver toxicity inherent in 17alpha-alkyated steroids. The health and legal risks are abstractions to most recreational users; the most concrete pain associated with injectable anabolic steroids use is pain.

Ask a type 1 diabetic about the impact of the condition on his life. Most become comfortable with dietary restrictions; it is the repeated injections and finger-pricks that are the least tolerable burdens. While recreational anabolic steroids users don’t prick fingers to monitor testosterone, many follow a frequent injection schedule. Contrary to insulin which is injected under the skin, anabolic steroids are injected deep into muscle tissue; typically the gluteus (butt muscle), but also shoulder or outer thigh. Some have a spouse/partner perform the injection, but most learn to self-inject.

A highly desirable advance in testosterone/anabolic steroids therapy would be to provide long-term sustainable release, avoiding dramatic peaks and troughs. Even the longest-acting esters currently available in the U.S. require bi-weekly injections; testosterone concentration fluctuates wildly with a three-fold difference between the highest and lowest concentrations experienced between shots. Bodybuilders avoid anabolic steroids lows by injecting more frequently, maintaining an anabolic concentration. During an anabolic steroids only cycle, bodybuilders endure two or more intramuscular injections weekly, depending upon the dosing schedule and number of anabolic steroids stacked. Competitive bodybuilders and athletes may compound this number with injections of insulin, growth hormone, inflammatory agents, prostaglandins, etc.

A testosterone ester has been developed and used clinically in many countries possessing the desired profile. Testosterone undecanoate has a decade-plus history of research and use in treating male hypogonadism (low testosterone). It is the preferred mode of hormone replacement for many men’s health specialists, due to its pharmacokinetic properties. Testosterone undecanoate is capable of maintaining a steady concentration of testosterone for 12 weeks in most users, up to 14 weeks in some. To reach a steady state, a 4 ml depot of Testosterone undecanoate in castor oil is injected, with a follow-up injection six weeks later; from then on, testosterone concentration is typically maintained with a 4 ml depot injected every 12 weeks. For American anabolic steroids users, or men receiving testosterone therapy, this sounds like nirvana— one shot every three months, rather than 12 or more.

Unfortunately, the FDA is being uncharacteristically slow in approving Testosterone undecanoate, due to the rare report of transient (short-term, like five minutes) shortness of breath that has occurred when the depot is improperly injected. Proper intramuscular injection technique requires that the plunger of the syringe be pulled back slightly to ensure that the drug is not being injected into a blood vessel, as this could allow the large globule to enter the bloodstream. If injected into a large vein, the globule could enter the pulmonary circulation (lungs) fairly intact, causing the sensation noted, until it is dispersed in the general circulation. Most anabolic steroids injections are limited to 2 ml or less.

One issue with Testosterone undecanoate that may affect compliance is a greater frequency or severity of injection-related pain. Four ml may not seem like a large volume, a teaspoon has 5 ml. However, when injected into the glute, 4 ml of an oil-filled depot can feel like one is sitting on a golf ball. Recently, a study was performed measuring relative pain associated with a 4 ml Testosterone undecanoate injection, and how long the pain lasts.25 This will likely be of interest to many men, as Testosterone undecanoate could quickly become the hormone replacement of choice in the U.S. when approved.

Those considering high-volume injections of other anabolic steroids, or hoping to acquire Testosterone undecanoate for recreational purposes, will likely find this worthy of note as well. Certain anabolic steroids, particularly veterinary preparations, are administered in low concentrations. In the study Australian clinicians followed 125 hypogonadal men receiving Testosterone undecanoate, administered as a single 4 ml intramuscular injection every 12 weeks; 43 returned during the study period for a scheduled injection, and their data were included in the analysis.

In reviewing these results, it is important to consider that the injections were provided in the clinic, by experienced nurses using proper injection protocol. The injections were provided slowly, over 3-5 minutes, through a 1½-inch, 21-gauge needle— the standard needle size used by doctors and bodybuilders for intramuscular injections. These results likely represent “best-case scenario” as a legitimate drug, properly injected, in a clinical setting by experienced practitioners. In the “real world,” the outcome is likely to be worse, with increased risk of other injection-related complications (e.g., bleeding, infection, injecting into a vein, tissue damage, and scarring).

The men were given a color-scale to represent the injection-related pain they experienced. They scored pain at the site just prior to the injection, immediately following, three more times that day approximately four hours apart, then each morning for eight days. All of these men had received Testosterone undecanoate previously, so they all were aware of the nature of the procedure.

As these men were all otherwise healthy, the pain score just prior to the injection was zero for nearly all subjects (96 percent), showing they were pain-free at the site of the injection. Nearly all subjects felt some degree of pain immediately post-injection (80 percent), ranging from annoying (2 on a scale of 10) to moderately-severe (pain score of 7). For most, the pain was worst immediately post-injection (58 percent), and resolved fairly quickly. In fact, none of the subjects reported that pain interfered with normal activities; in all cases, the pain resolved in three days or less.

The authors compared this to an earlier study examining pain associated with a 1 ml intramuscular injection of testosterone enanthate. In this, most men did not experience reportable pain; only 29 percent noted any injection-related discomfort. The difference between the Testosterone Enanthate and Testosterone undecanoate experience is likely related to the volume of the injection (1 ml versus 4 ml).

Two traits were noted that were associated with less pain— age and obesity. Older men reported less pain than their younger counterparts; this may be due to reduced pain sensitivity that occurs with aging, or they may just be more stoic. Obese men have a much thicker subdermal (under the skin) fat pad. In some men, this may be thicker than the length of the needle, causing the 4 ml depot to be dispersed among the less reactive adipose tissue (fat), as opposed to the acutely sensitive muscle. Though this has been noted to be an issue, it appears drug delivery may be equally effective when injected as an oil depot into fat or muscle. Most normal-weight or lean men would not find the visible bulge from the injection comfortable or tolerable cosmetically.

One reasonable question is, “Why not divide the shot into two injections of 2 ml, one into each butt cheek?” After all, if pain is this common and can be severe for some, why not make the process more tolerable? Most bodybuilders who have used injectables for many cycles can share the hassles: left-handed injections for right-handers; cheap needles with blunt tips; accidentally flexing the glute while the needle is embedded; trying to inject more than 2 ml at once; and the formation of a lipoma (oil mass in the muscle from frequent injections into the same space). Some bodybuilders have had surgery to remove an abscess caused by the injection.

The advantage of injecting a single large bolus, rather than two or more smaller depots, is that a large globule releases the drug much more slowly. Within muscle cells, fat or oil tends to form a spherical globule. One large globule better protects the drug inside, insulating Testosterone undecanoate from esterases— enzymes that release testosterone from the pro-drug ester. Testosterone undecanoate increases testosterone concentration only after it is released from its attached ester. It appears as though the U.S. version will be administered as a 3 ml injection, every 10 weeks.

Therapeutically, Testosterone undecanoate offers a very convenient and reliable means of keeping testosterone levels at a suitable concentration. The only requirement will be to attend a clinic for an unusually voluminous injection; some people may be able to administer this at home. For the recreational user, if one is not willing to undergo a 4 ml injection, the time course of dispersion will not be the 12-week window seen with clinical use. The kinetics of this drug given as a 1 ml injection would likely be similar to Deca-Durabolin (nandrolone decanoate), which is esterified to a 10-carbon tail, as opposed the 11-carbon tail used in Testosterone undecanoate.

Testosterone undecanoate is an exciting advance in testosterone replacement. However, for those looking to use it more frequently to maintain a supraphysiologic concentration over an extended period, Testosterone undecanoate may require big (or at least annoying) pains for big gains.

Reblogged 2 years ago from cuttingcyclesteroids.tumblr.com

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Reblogged 2 years ago from www.amazon.com

Steroid Cycles and Keeping Muscle Gains

One question potential anabolic steroid users frequently ask is, How long do muscle gains last after you get off a steroid regimen? Some people think that’s a trick question, since many scientists still believe that the majority of gains produced by steroids consist largely of water. In fact, official position statements of several sportsmedicine organizations declare that any gains following steroid use are likely more water than muscle. On the other hand, muscle is 72 percent water anyway. Solid gains would consist of protein and the connective tissue components of muscle. They’d tend to be more permanent than the ephemeral bloat characteristic of pure water gains. Exercise favors protein and connective tissue gains, although, depending on several other factors, such as diet, water may also accompany muscle gains and be reflected on the scales.

Doubts about the genuineness of steroid-induced gains arise from casual observations that many steroid-using athletes don’t appear to be as massive when they aren’t taking the drugs. That leads to the impression that the previously displayed muscle size must be temporary and can only be maintained with a constant steroid regimen.

Another frequent observation is that while the drugs appear to promote muscular gains, they also seem to favor bodyfat losses. That’s readily apparent when you compare so-called natural bodybuilding competitors to their steroid-using peers. The drug users are not only usually more massive, but they also appear to show a far greater degree of muscular definition than the naturals. The effect is so common, in fact, that some bodybuilders who swear they’re natural are often suspect due to their steroidlike degree of muscularity. The consensus is that you just can’t get super-ripped without resorting to drugs.

So the question is, How do anabolic steroid drugs actually affect body composition, and how long do you retain gains after you stop using them? Those questions and others were examined in a recently published study that featured 35 experienced male strength athletes, 19 of whom self-administered anabolic steroids, while 16 were clean.

To assess the men’s body composition, the researchers measured body circumferences at baseline, eight weeks and six weeks after steroid withdrawal (in the steroid users). Since another goal involved determining any differences between effects noted with short- vs. long-term steroid use, nine of the steroid users took the drugs for eight weeks, while 10 others took them for 12 to 16 weeks.

Of those in the study, 28 considered themselves bodybuilders, yet only seven competed in bodybuilding contests. While several of those subjects got their drugs with a physician’s prescription, most purchased the drugs on the black market. They designed their drug regimens after conversing with other athletes and experimenting on their own. The drugs consisted of typical injectable anabolic steroids, such as various types of nandrolones, testosterone and oral drugs such as Stanozolol (Winstrol). One key point is that all of the steroid users took a combination of drugs, a process known as stacking.

After eight weeks the steroid users showed a significant lean body mass increase of 4.5 kilograms, or just a tad under 10 pounds. In contrast, the nondrug users showed no significant changes in lean mass or weight gain. The percentage of fat in the steroid group dropped 1 percent, yet it wasn’t reflected in any loss of muscle mass. The gains in lean mass made by the steroid group persisted after the subjects had been off the drugs for six weeks.

The steroid users also showed size gains in the neck, upper arm, forearm, wrist, thigh and calves that were significantly greater than the nondrug group experienced; however, the measurements of chest circumference, waist and buttocks didn’t differ significantly between the groups.

The size gains made by the steroid users did decrease slightly when they stopped using the drugs but still remained greater than they’d been at the start of the study. Another interesting finding was that gains made by the long-term steroid users weren’t significantly different from those made by the short-term users. The authors think that debunks the long-held idea that a longer steroid cycle produces greater gains.

Another curious result was that the lean mass gains made in the upper arms of the steroid users were twice those of the legs or trunk areas. That wasn’t the result of any training differences, since all subjects trained with similar levels of exercise volume and intensity. It led the authors to conjecture that steroid stacks may affect specific body areas more than others. Taking that a step further, they’re saying that using certain drugs may target some muscle areas more than others. They mention a previous study that found greater gains in the legs and trunk after subjects used nandrolone drugs, such as Deca-Durabolin.

The researchers also carefully measured the composition of the lean mass gains made by the steroid group. While some of the gains did include water, the majority were clearly muscle. They also note that the usual practice of getting back on drugs several weeks after being off, when gains start to recede, appears to make sense, although they warn that the long-term health effects of such cycling remain unknown.

A study published nine years ago examined the effects of body composition changes in seven healthy young men, ages 20 to 24, none of whom were bodybuilders and only one of whom exercised, after they received injections of testosterone enanthate for 12 weeks.2 The study began with five of the subjects getting a 0.75-milligram per kilogram injection of testosterone for four days. Then all seven subjects received a three-milligram per kilogram weekly dose for 12 weeks. That amounts to about 270 milligrams weekly for a 200-pound man, not considered a hefty dose of testosterone. In contrast, a later study that proved the lean-mass-building effects of testosterone used a dose of 600 milligrams a week.

Despite the paltry dose of testosterone provided in this study, the subjects still managed to average a 16-pound gain in lean body mass, which reflected a 12 percent increase above baseline lean mass measurements. They also lost an average of 3.4 kilograms of bodyfat, or 27 percent less than starting values. So a low dose of just one steroid drug led to gains in lean mass coupled with significant fat loss’even in a group that didn’t exercise!

After the subjects stoped getting testosterone injections, the lean mass gains gradually declined to the point where half were gone in two months; however, five to six months after they stopped using the drug, they still showed more lean mass than they had at the start of the study, indicating that the muscle gains were longer lasting than most people expect.

The study concluded with the observation that anabolic steroids promote greater lean mass gains than can be achieved with exercise alone and that such gains consist nearly entirely of muscle. That’s the same conclusion arrived at by a study that used a 600-milligram dose of testosterone, four years after the initial study was published.

At the risk of belaboring the obvious, anabolic steroids do work, and the gains produced are mostly muscle coupled with a significant loss of fat, particularly subcutaneous fat. While some of the muscle increase does decline after the end of a steroid regimen, much of it remains, especially if you continue to train hard and eat correctly.

I also want to add one other observation: If you start with two people who had comparatively equal genetic bodybuilding abilities and put one of them on a steroid-stacking regimen, the drug user will nearly always defeat his or her natural counterpart in bodybuilding or another athletic competition. That’s because drugs such as anabolic steroids provide increased training recovery, as well as greater degrees of muscular size and definition. Anyone who disputes that notion is either dishonest or naive. From a health and longevity viewpoint, however, the odds are likely in favor of those who shun drug use, especially long-term use. IM

Reblogged 3 years ago from cuttingcyclesteroids.tumblr.com

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Reblogged 3 years ago from www.amazon.com